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产品名称: |
徕卡Bcl-2 Oncoprotein蛋白抗体 |
产品型号: |
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产品产地: |
中国大陆 |
访问次数: |
1518 |
发布时间: |
2016/3/28 15:40:16 |
Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. |
徕卡Bcl-2 Oncoprotein蛋白抗体 Clone bcl-2/100/D5 7 mL BOND ready-to-use PA0117 P (HIER) Antigen Background Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway. In 90 percent of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas. Also available as a liquid concentrate, refer to page 98
Human diffuse large B cell lymphoma: immunohistochemical staining for Bcl-6 using PA0204. Note nuclear staining of neoplastic cells. Paraffin section.
更新时间:2024/4/3 14:23:06 标签: 蛋白抗体 Bcl-2蛋白 Leica克隆抗体
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